Melatonin Receptor 1A Gene Polymorphism Associated with Polycystic Ovary Syndrome

Background/Aims: Melatonin receptor 1A (MTNR1A) gene is a regulator of circadian rhythms and reproductive processes. The MTNR1A gene is also a potential candidate gene of polycystic ovary syndrome (PCOS). The aim of the present study was to determine whether or not the MTNR1A gene polymorphism is associated with a predisposition to PCOS. Methods: The single nucleotide polymorphism (SNP) rs2119882 in the MTNR1A gene was detected in 482 patients with PCOS and 522 healthy Chinese Han women. Subsequently, the association of MTNR1A gene variants with plasma glucose, insulin levels during oral glucose tolerance tests (OGTTs) and hormone levels was investigated. Results: The frequencies of genotypes and allelotypes of SNP rs2119882 differed significantly between PCOS cases and healthy controls (p ! 0.001 and p = 0.002, respectively). SNP rs2119882 was associated with higher fasting plasma glucose concentrations (p = 0.021) and OGTT-induced insulin release at 0, 30, 60, and 120 min (all p ! 0.05) in PCOS cases, as well as an increased homeostasis model assessment for insulin resistance (p = 0.005). Conclusion: SNP rs2119882 is associated with PCOS. Copyright © 2011 S. Karger AG, Basel Received: August 8, 2010 Accepted after revision: December 12, 2010 Published online: April 7, 2011 Zi-Jiang Chen, MD, PhD Shandong Provincial Key Laboratory of Reproductive Medicine , Center for Reproductive Medicine , Provincial Hospital Affiliated to Shandong University Jinan, Shandong 250021 (China) Tel. +86 132 5555 9046, E-Mail chenzijiang @ hotmail.com © 2011 S. Karger AG, Basel 0378–7346/11/0722–0130$38.00/0 Accessible online at: www.karger.com/goi C.L. and Y.S. contributed equally to this work. D ow nl oa de d by : 54 .7 0. 40 .1 1 10 /6 /2 01 7 5: 54 :0 1 A M